FGF-acidic human rec.

FGF-acidic human rec.

Product description

Acidic fibroblast growth factor (FGF-1) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro. Three alternatively spliced variants encoding different isoforms have been described. These heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these growth factors. FGF-1 human recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 140 amino acids and having a molecular mass of approximately 15.8 kDa. The FGF-1 is purified by proprietary chromatographic techniques. Synonyms: HBGF-1, ECGF-beta, FGFIBP, FIBP-1, ECGF, ECGFA, FGF1, FGF-a